Phenolic compounds that modulate Multi Drug Resistance through inhibiting of P-glycoprotein encoded by gene ABCB1

One of the most important challenges in fight against cancer is acquired drug resistance. P-glycoprotein (P-gp), encoded by ABCB1 gene many organs, one factors involved development P-gp mainly efflux toxic substances such as xenobiotics from cell. In addition to these, it also plays a role drugs used treatment cancer, rate success reduces. Phenolic compounds are chemicals that naturally synthesized plants and have biological activities, especially antioxidant anticancer. previous studies, was determined their anticancer phenolics modulate resistance inhibiting expression function P-gp. this review, phenolic play breaking multi-drug activation discussed.